The problem is that conda python not a "python framework" on Mac, their solution is that you should use pythonw . Unfortunately, pip creates entry-point scripts using python not pythonw , and, even worse, RunSnakeRun does a terrible subprocess dance to start itself in 32-bit mode on 64-bit poppies.
The result is that the only hacky workaround I can come up with for running runsnake is as follows:
VERSIONER_PYTHON_PREFER_32_BIT=yes pythonw `which runsnake32`
Actually, I'm not sure if the environment variable is needed even more, but the above does what it tries to create an entry point, and at least runs the RunSnakeRun GUI.
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