You can use BASH string manipulations (you need to exit / with \/ ):
s='6427//6422 6429//6423 6428//6421' echo "${s//\/\//,}" 6427,6422 6429,6423 6428,6421
Similarly, using awk:
awk -F '//' -v OFS=, '{$1=$1}1' <<< "$s" 6427,6422 6429,6423 6428,6421
PS: tr cannot be used here, since tr translates each character in the input of another character in the output, and here you are dealing with 2 // characters.
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