The recommended level of consistency for lightweight transactions is SERIAL. However, behind the scenes, SERIAL is worse than QUORUM because it is multiphase QUORUM. As you said, the situation may become more complicated if you have several DC-Datastax, evaluating "degradation is effective to one third of normal . "
There is LOCAL_SERIAL, which may be ideal for your situation when all domain controllers receive data from a specific DC current.
Here you can find additional information:
LIGHT OPERATIONS
LINEARIZATION CONSULTATION
NTN, Carlo
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