/WebResource.axd is usually requested because the page contains a link to it, often img src:
<img ... src="/WebResource.axd..." />
usually generated from ASP.NET WebControl, for example. menu control.
I would recommend that you find the page containing the WebResource.axd link, see how and why it is created, and why it is invalid. For example, you can look at the IIS server logs to find which page immediately precedes the WebResource.axd request, or you can add your own log to Application_BeginRequest.
Once you recognize the abusive page and determine which control on the page generates the request, ask again here.
I saw this in the past on a static HTML page containing HTML (like a menu) that was copied and pasted from the displayed ASPX page. The request is invalid on a static HTML page, and the fix was just to remove the abusive img element.
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