This is not possible with tmux 2.0.
However, one thing you can do is send commands to the incoming tmux session from the shell. This means that you can create, for example, a bash alias that can split windows:
alias vsp="tmux split-window -h"
You can then start vsp from the bash prompt to split the tmux window vertically. Depending on your specific use case, this may help.
It is also worth noting that if minimizing typing is the goal, tmux commands can be shortened to their shortest unambiguous prefix: sp does the same thing as split-window .
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