I would like to package a scientific Python application for PyPI. My problem is that it uses PyPI level fingerprints (e.g. numpy, scipy, etc.), as well as others that need to be processed at the OS level: wxPython and Python-VTK (e.g. from apt-get on Ubuntu , homebrew on OSX, etc.).
I would like to know what would be the ideal strategy for this, and in particular which packaging system is best suited (I currently prefer Distribute).
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