You can use search and replace:
:%s/..\zs...\ze
or in a more general form:
:%s/.\{2}\zs.\{3}\ze
where the first number (2) is the column index (based on zero), and the second number (3) is the number of characters the column has.
Explanation:
:%s/
search and replace in the entire buffer.
.\{2}\zs
find two characters and set the start of the match here.
.\{3}\ze
find three characters and set the end of the match here.
Omit the replacement string as you want to remove the match.
NTN
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