I am using Django Compressor and I am very pleased with this. It supports pre-processors, so Coffeescript, Sass, etc. are supported. Check the documentation.
EDIT: Here are my settings for SASS and Coffeescript, in settings.py:
STATICFILES_FINDERS = ( 'django.contrib.staticfiles.finders.FileSystemFinder', 'django.contrib.staticfiles.finders.AppDirectoriesFinder', 'compressor.finders.CompressorFinder', ) COMPRESS_PRECOMPILERS = ( ('text/coffeescript', 'coffee --compile --stdio'), ('text/x-sass', 'sass {infile} {outfile}'), ('text/x-scss', 'sass --scss {infile} {outfile}'), )
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