Actually, you can, which can come in handy when you do StringFormat in data-bound Textblock or in a number of other places.
If you really want to try, as here, the SL example is for a form label that places a red star next to the text "Required fields", but then can also add more things to it, as shown in the example. Should work for Silverlight, WPF, UWP, etc.
<TextBlock> <Run Text="*" Foreground="#FFE10101"/><Run Text="Required Line" /> <Run Text="Red" Foreground="Red"/> <Run Text="Blue" Foreground="Blue"/> <Run Text="{Binding SomeString, StringFormat='Hell ya you can make \{0\} a different color!'}" Foreground="Orange"/> </TextBlock>
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