If you use C # rather than targeting Webplayer or iOS, you can use HttpWebRequest and a library like Json.NET if you want (if you have experience with this class instance). You will likely have to spend a little extra time processing the request correctly asynchronously.
There is also a Unity WWW class , where you will check and analyze the resulting text property. The WWW class has the advantage of requiring very little code to execute the request asynchronously.
Please note that without an asynchronous request, you can easily block progress in the rest of the game loop, which is almost always undesirable.
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