To a certain extent, yes. Zappa is a very new structure in a very active development. I wrote the application in it in July, and since then two incompatible updates have passed in the infrastructure. In such an environment, it is often useful to understand what infrastructure does behind the scenes.
Also, since the coffee script allows mixing in JavaScript libraries (and Zappa itself does this), their documentation will provide examples in JavaScript - so you can speak JavaScript freely.
On the other hand, the experience with Node is not so important in itself, since Node provides a fairly minimal API, which for the most part is well abstracted by Express.js (also a component of Zappa). Most of what you need to know about Node can be found in the afternoon.
TL DR Ignorant coffee and JS could very well be a problem without knowing Node not so much.
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