If the creator of the TIFF writes a well-managed TIFF, each channel must be normalized to the full dynamic range of that channel. In other words, 16 bits per channel should be in the range from 0-65535, 8 bits per channel should be in the range from 0 to 255.
While the number of bits used could be encoded into a tag, there are no basic tags that encode it. This means that if a 10-bit device does not normalize to 16 bits, there is no way for the basic reader to understand the intent of the image.
As a third-party note, there are other image file formats (Dicom - one) that provide a way to express how many bits per channel are significant.
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