Yes. There are some differences:
- Whether it is a block cipher or not, you can guess the length.
- Block length
- Output entropy (are all characters equally present? / Can patterns be found?)
- Repetitions ( CBC or not ...)
Entropy row is probably the best hint. An easy way to determine this is probably trying to compress it. Some methods can be found here: http://www.random.org/statistics/ They use them to make sure their numbers are as random as possible.
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