You can use cfexecute to run the command line on the CF server.
Karthik related a blog post suggesting the following syntax for ffmpeg:
ffmpeg -itsoffset -4 -i test.avi -vcodec mjpeg -vframes 1 -an -f rawvideo -s 320x240 test.jpg
So you can do something like this:
<cfexecute
name="c:\pathto\ffmpeg\ffmpeg.exe"
arguments="-itsoffset -4 -i #sourcevideo# -vcodec mjpeg -vframes 1 -an -f rawvideo -s 320x240 #thumbnaildestination" />
ffmpeg, , , , , , .
, fmpeg.exe , ColdFusion.