Django can do this, but I find it best to use the Javascript framework ondop django, currently I'm doing it. ExtJS has various types of grids in your situation. I think the "Live" grid would be perfect.
It loads x the number of lines, so you don't need to load 100,000 lines every time, just what the user sees. In addition, built-in filters, etc., as well as many other functions.
Other javascript frameworks that do similar things are YUI, and in my opinion, jQuery is less so
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