In TkProf, you can mainly specify the number of round trips as the number of “calls” (although there are exceptions, so fewer round trips are required, for example, parse / execute / fetch to select one line, theoretically, it is possible in one round-the-world trip, the so-called "exact selection" of the oracle). However, as an estimate, tkprof performance is pretty good.
If there are trace wait events, you should directly see the "SQL * Net from / to client" wait events in the source trace, but I think tkprof does not show this (not sure, try it).
Another way is to view session statistics:
select value
from v$mystat ms, v$statname sn
where ms.value > 0
and ms.statistic
and sn.name IN ('SQL*Net roundtrips to/from client')
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