If you want to stay with the Native API, then MFC is still a good choice or a simple Win32 API.
New controls have appeared, such as ribbon management introduced in VS2010. There's a tutorial on native development from VS2010 on MSDN . There are also many C ++ 0x features available to your native program if you are using VS2010.
Qt - , , VS 2010. LGPL.
, WPF Microsoft, (.NET). - Silverlight . Silverlight , Mac, Silverlight. Winforms - , WPF.
, , WPF, MFC. . ( # ++/CLI). WPF GPU.