No, Windows Script Host does not support Script calls asynchronously. To achieve this effect, you will have to run two scripts at the same time:
var oShell = new ActiveXObject("WScript.Shell");
oShell.Run(WScript.FullName + " say.js Hello");
WScript.Echo("Hello from main");
WScript.Sleep(5000);
WScript.Echo(WScript.Arguments.Item(0));
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