I already said this in the comments, but since no one sent an answer ... :)
Unfortunately, nothing has changed in the world of web design - it still consists in getting the damn thing to work in IE. This is much better if you do not need to support IE6, but it's still the same old trial and error process. No one has yet provided a magical framework for resolving these problems.
The only possible difference is that there is much more reading and documentation on specific issues, so if you run into a CSS problem, maybe someone wrote about it.
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