You can use the OnClick event handler when programmatically changing the state of the radio exchange:
procedure TForm1.Button6Click(Sender: TObject);
var
Save: TNotifyEvent;
begin
Save:= RadioButton2.OnClick;
RadioButton2.OnClick:= nil;
RadioButton2.Checked:= not RadioButton2.Checked;
RadioButton2.OnClick:= Save;
end;
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