I would think that you can use ClickOnce to deploy it on Windows computers. ClickOnce will not work for anything else (of course). I don’t know what tools you use for Mono, but you can try using MageUI or Mage to create a deployment from files and see if it works.
You also need these MIME types if you are targeting .NET 3.5:
.msp -> application / microsoftpath
.msu -> application / microsoftupdate
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