There is a very interesting structure called DotLess .
dotLess is actually the .LESS port for ASP.Net. The structure is implemented as an ASP.Net handler and works for files with .LESS extensions, like LESS.
I tried to implement it in one of my projects, but for some reason, when it worked on my dev machine, I could not get it to work on the server. This was more than 6 months ago, although the implementation of this issue is still on my agenda. When I'm a little busy.
I would definitely recommend it.