You can set UpdateMode='Conditional', then set which buttons you want to call after feedback in the tag <Triggers>. Something like that:
<asp:UpdatePanel ID="UpdatePanel1" runat="server" UpdateMode="Conditional">
<Triggers>
<asp:PostBackTrigger ControlID="button1" />
</Triggers>
<ContentTemplate>
...
<asp:Button ID="button1" runat="server" Text="Click Me" />
</ContentTemplate>
</asp:UpdatePanel>
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