Why do you need 100 pieces?
You will have a simple “Follows” table with your identifier and the identifier of other persons in it ...
Then you extract the “Tweets” by attaching something like this:
Select top 100
tweet.*
from
tweet
inner join
followers on follower.id = tweet.AuthorID
where
followers.masterID = yourID
Now you just need decent caching and make sure you're using a non-blocking request and you have all the information ... (Well, maybe add some user data to the mix)
Edit:
tweet
ID - tweetid
AuthorID - ID of the poster
Lecture hall
MasterID - (Basically your ID)
FollowerID - (ID of the person following you)
Followers master followerID
2 - "masterID - followerID" "FollowerID MasterID"