The current version of IronPython (v2.0) does not seem to be consistent with the nose. This may have been fixed in 2.6, but I have not yet repeated my test to figure it out. So, so far you are only an option - if someone has not experimented with one of the other python testing frameworks - pyunit - this is just your choice.
You can also check out the fake fake framework created by Michael Foud, which pretty much guarantees that it will work perfectly with IronPython. If I remember correctly, he even shows some examples in his IronPython book in action.
Finally, you should probably check out this link from the cheesecake project for a few other tools that might interest you.
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