It depends on the specific modules you are using. I am running several 64-bit Linux systems, and I still have to deal with problems with any of the C modules that I use.
Most C modules can be built from the source, so you should read about the Python distutils distribution utility to find out how you can create these modules if you cannot find 64-bit binaries.
Whether a particular module will work in a 64-bit environment depends on how the code was written. Many modules work correctly when compiled for 64-bit, but there is a chance that this will not happen. Many popular modules, such as SciPy , work fine.
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