You need to make sure UseSubmitBehavior is set to false in the markup, then you need to make sure that you return false before the javascript postback is called.
Edit:
You must return the value of your function, and then in the retrun function true if you want to receive the postback, and return false if you do not.
<asp:Button ID="Button1" runat="server" Text="Submit" onclick="Button1_Click"
OnClientClick="return Check();" UseSubmitBehavior="false" />
JavaScript:
function Check()
{
return confirm(" Are u sure whatYou have selected ");
}