This is an ideal task that can be solved with AJAX. You can set some kind of timer to start, which starts as soon as the user makes a change on the client side, and then he will make an asynchronous client client connection back to your server to send the contents of the wysiwyg field. You can then turn off the timer until the user starts editing again to avoid the need for asynchronous calls.
This will certainly prevent user interruption via postback.
There are many ways to do this, but the following msdn link would be a good start:
http://msdn.microsoft.com/en-us/library/bb398785.aspx
Essentially, this gives you an overview, but the main bit that you need to focus on is viewing javascript web services:
http://msdn.microsoft.com/en-us/library/bb398998.aspx