This is a well-known issue with the workflow designer in visual studio 2008. We were promised improvements in sp1 (and presumably got them, but I didn't notice anything). Offers include:
Move all types used in workflows to a different project than where workflows live.
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: http://blogs.msdn.com/madhuponduru/archive/2008/09/30/workflow-designer-and-performance.aspx
-Oisin