I used YUI grids on several sites and found it in combination with fonts and Reset components to provide very high quality cross-browser sites. This design serves various purposes up to 960.gs, and a quick look at your storyboard site will indicate which is more suitable.
YUI nets can be nested to achieve element separation, and it is usually easy for me to work.
I would say that using Reset css is crucial and works with any grid that you find most comfortable.
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