I would try to think about a tag domain and find out what is the likelihood that potential tags will contain spaces.
For example, most of the things on this site are one word or acronyms, so itβs easy to use spaces.
On the other hand, when marking Facebook, for example, the middle tag is something like "spring break", "frat party", "random hookup", "secretary of state" , etc. Thus, dealing with spatial interpretation or with quotation marks is more complicated, so commas make more sense.
I am not familiar with a certain rule.
If you are thinking about tag clouds, spaces make sense.
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