If your EXE is not a COM object or does not export certain functions, such as a DLL, this is not possible.
For the COM method, consider these resources:
For exported functions, such as the dll method, use the python win32 module along with the LoadLibrary Win32 API and related functions.
If you have access to the source code of the EXE:
EXE, , . ps. os.system subprocess.call().