This is a pretty big subject, but you should use AJAX to improve the user interface without making the site completely dependent on it. Remember that search engines and some other visitors will not be able to perform AJAX, so if you rely on it to upload your content, this will not work in your favor.
For example, you might think that it would be nice if users visited your blog and then the page was dynamically loaded with the latest articles using AJAX as soon as they are already there. However, when Google tries to index your blog, it just gets a blank site.
, , " ". , , . , :
http://www.alistapart.com/articles/progressiveenhancementwithjavascript/