One possible way to customize your user interface is to override the following two theme resources: NavigationViewDefaultPaneBackgroundand NavigationViewExpandedPaneBackground.
Usually you modify these two resources to customize the appearance of the acrylic brush, overriding them as follows:
<AcrylicBrush x:Key="NavigationViewDefaultPaneBackground"
BackgroundSource="Backdrop" TintColor="Blue" TintOpacity=".6"/>
I would think that you can simply define SolidColorBrushinstead of AcrylicBrush, so changing the acrylic background to a solid color and completely removing acrylic from the NavigationView panel.
<SolidColorBrush x:Key="NavigationViewExpandedPaneBackground" Color="Red"/>
<SolidColorBrush x:Key="NavigationViewDefaultPaneBackground" Color="Red" />