Set Bas an index first to use the method Groupby.resampleon it.
df.set_index('B', inplace=True)
A . , ffill ( fillna NaN 0).
rolling, 4 (- freq=4s) C, :
for _, grp in df.groupby('A'):
print (grp.resample('s').ffill(limit=0).rolling(4)['C'].mean().head(10))
:
B
2016-01-01 09:30:00 NaN
2016-01-01 09:30:01 NaN
2016-01-01 09:30:02 NaN
2016-01-01 09:30:03 1.5
2016-01-01 09:30:04 2.5
2016-01-01 09:30:05 3.5
2016-01-01 09:30:06 4.5
2016-01-01 09:30:07 5.5
2016-01-01 09:30:08 6.5
2016-01-01 09:30:09 7.5
Freq: S, Name: C, dtype: float64
B
2016-01-01 09:30:00 NaN
2016-01-01 09:30:01 NaN
2016-01-01 09:30:02 NaN
2016-01-01 09:30:03 21.5
2016-01-01 09:30:04 22.5
2016-01-01 09:30:05 23.5
2016-01-01 09:30:06 24.5
2016-01-01 09:30:07 25.5
2016-01-01 09:30:08 26.5
2016-01-01 09:30:09 27.5
Freq: S, Name: C, dtype: float64
B
2016-01-01 09:30:12 NaN
2016-01-01 09:30:13 NaN
2016-01-01 09:30:14 NaN
2016-01-01 09:30:15 33.5
2016-01-01 09:30:16 34.5
2016-01-01 09:30:17 35.5
2016-01-01 09:30:18 36.5
2016-01-01 09:30:19 37.5
Freq: S, Name: C, dtype: float64
TL; DR
groupby.apply :
df.groupby('A').apply(lambda grp: grp.resample('s').ffill(limit=0).rolling(4)['C'].mean())
()
df.groupby('A').apply(lambda grp: grp.resample('s').ffill().rolling(4)['C'].mean())
.