You need to use XDocument
const string xml = "<Misc><E_Mail>email@domain.xyz</E_Mail><Fax_Number>111-222-3333</Fax_Number></Misc>";
const string tagName = "E_Mail";
XDocument xDocument = XDocument.Parse(xml);
XElement xElement = xDocument.Descendants(tagName).FirstOrDefault();
if (xElement == null)
{
Console.WriteLine($"There is no tag with the given name '{tagName}'.");
}
else
{
Console.WriteLine(xElement.Value);
}