You can do this with the captured group in regex, use regex and replace it with the captured value
"(\d+)"
CODE:string contents="\"000027679\",\"ROMANO\",\"CRYSTAL\",\"S\",\"FT\",\"19990706\",\"19990706\",\"A\",,\"006901\"";
string newcontent = Regex.Replace(contents,@"""(\d+)""", "$1");<hr>
OUTPUT:
000027679,"ROMANO","CRYSTAL","S","FT",19990706,19990706,"A",,006901
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