pandascalls scipyinterpolation procedures, I'm not sure why it is 'cubic'so hungry and slow.
method='spline' (scipy ref ), (, ?) .
In [104]: # create series
...: size = 2000
...: x = np.linspace(-2, 5, size)
...: y = pd.Series(np.sin(x))
...:
...: # deleting data segment
...: y[10:30] = np.nan
...:
In [105]: %time cubic = y.interpolate(method='cubic')
Wall time: 4.94 s
In [106]: %time spline = y.interpolate(method='spline', order=3, s=0.)
Wall time: 1 ms
In [107]: (cubic == spline).all()
Out[107]: False
In [108]: pd.concat([cubic, spline], axis=1).loc[5:35, :]
Out[108]:
0 1
5 -0.916444 -0.916444
6 -0.917840 -0.917840
7 -0.919224 -0.919224
8 -0.920597 -0.920597
9 -0.921959 -0.921959
10 -0.923309 -0.923309
11 -0.924649 -0.924649
12 -0.925976 -0.925976
13 -0.927293 -0.927293