The prefix \\?sends paths directly to the file system without preprocessing.
The prefix \\.bypasses the file namespace and uses the Win32 device namespace.
They have separate goals and cannot be mixed.
You can try it yourself. For example, this will open the null device:
HANDLE hDevice = ::CreateFileW(L"\\\\.\\NUL", GENERIC_WRITE, FILE_SHARE_READ | FILE_SHARE_WRITE, 0, OPEN_EXISTING, 0, 0);
L"\\\\?\\\\.\\NUL", .
, , \\? .