You can use ng-change="[second='', first='']"to clear the input fields, otherwise, if you want more functions to be executed during on-change, use the function callng-change="someFunction()"
just if you want to clear the input field you specified in jsfiddle you can try this
Working code
<div ng-controller="MyCtrl">
<table>
<tbody>
<tr>
<td ng-hide="myOption=='one'"><input ng-model="first" ng-hide="myOption=='one'"></input></td>
<td ng-hide="myOption=='one' || myOption=='two' "><input ng-model="second" ng-hide="myOption=='one' || myOption=='two' "></input></td>
</tr>
</tbody>
</table>
<select ng-model="myOption" ng-change="[second='', first='']">
<option value="one">test1</option>
<option value="two">test2</option>
<option value="three">test3</option>
</select>
</div>