I ran into the same problem and was able to solve it by specifying the following lines in the application.conf file (thanks to help from play-slick contributors here ):
db.default.slickdriver=com.typesafe.slick.driver.ms.SQLServerDriver
db.default.driver=com.microsoft.sqlserver.jdbc.SQLServerDriver
jTDS sourceforge, .
db.default.slickdriver=com.typesafe.slick.driver.ms.SQLServerDriver
db.default.driver=net.sourceforge.jtds.jdbc.Driver
, sqljdbc4.jar ( ) {play app root}/lib.
jTDS build.sbt, .