Yes it is possible. You need to delve into the methods from PyTables that you depend on HDFStore.
Out[20]:
<class 'pandas.io.pytables.HDFStore'>
File path: test.h5
/a frame (shape->[3,1])
In [21]: store.get_node('a')._f_rename('b')
In [22]: store
Out[22]:
<class 'pandas.io.pytables.HDFStore'>
File path: test.h5
/b frame (shape->[3,1])
The same method works on frame_tablejoining nodes.
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