Drop is a very flexible method, and it can be used in several ways:
In [11]: mi = pd.MultiIndex.from_product([['col1', 'col2', 'col3'], ['a', 'b']])
In [12]: df = pd.DataFrame(1, index=[0], columns=mi)
In [13]: df
Out[13]:
col1 col2 col3
a b a b a b
0 1 1 1 1 1 1
Drop one column using a tuple:
In [14]: df.drop(('col1', 'a'), axis=1)
Out[14]:
col1 col2 col3
b a b a b
0 1 1 1 1 1
or a list using a list of tuples:
In [15]: df.drop([('col1', 'a'), ('col2', 'b')], axis=1)
Out[15]:
col1 col2 col3
b a a b
0 1 1 1 1
or through a level, for example. all as:
In [16]: df.drop('a', level=1, axis=1)
Out[16]:
col1 col2 col3
b b b
0 1 1 1
At 0.14, you can also pass in the regular expression of what needs to be removed ...
/:
In [21]: df.columns.droplevel(1)
Out[21]: Index([u'col1', u'col1', u'col2', u'col2', u'col3', u'col3'], dtype='object')