Use np.array to build the array, then reshape to turn it into the desired shape:
>>> np.array([[[[1, 2, 3, 4], [5, 6, 7, 8]], [[9, 10, 11, 12], [13, 14, 15, 16]]]]).reshape((4,4)) array([[ 1, 2, 3, 4], [ 5, 6, 7, 8], [ 9, 10, 11, 12], [13, 14, 15, 16]])
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