Generally not.
However, there are some situations where you can change some specific configuration parameters at runtime, see for example:
However, it is probably a good idea to try changing the JVM arguments at runtime - they are intended for one-time setup of the runtime. If you find that you want to change the JVM arguments at runtime, I suspect that something is wrong with your design in your case, and you should look at alternative ways to achieve your goal.
source share