I will repeat what aland said and add your own experience.
I worked with several computing clusters equipped with Fermi and tested them with ECC on and off. We did this to increase the amount of available memory and the speed of calculations, which was noticeable. nvidia-smi never reported ECC errors for these cards with ECC, and we did not encounter run-time errors that indicated problems with ECC.
If your card detects irreparable problems with ECC, this indicates a lack of hardware, and disabling ECC only masks the problem. The runtime correctly warns you that something bad has gone wrong and you cannot depend on the results.
In any case, you can try to carry out your calculations and see what happens, but be prepared for something completely insane for no real reason. One bit is flipped over here or it can have huge consequences for floating point math, for example, and can align your kernel if the command is corrupted.
If you can, I would try replacing the card instead of masking the symptoms.
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