The subscript is your target response time for this level. In the user agent (browser), the high water mark is 7 seconds. You should check only US-Only and make this number 2 to 4 seconds for world class.
The application server tier should respond much faster. The default high water mark set by NR is 0.5 seconds or 500 milliseconds, with an average world-class page buffer level of 50-200 ms on average.
Remember that all this information refers to aggregated averages, and not to instance data, which will have a lot of outliers and be widespread.
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