Yes, now you can with Chrome 17 .
Add the source page and webRequest permissions to manifest.json:
{ "background_page": "background.html", "permissions": [ "webRequest", "webRequestBlocking", "http://www.mozilla.org/*" ] }
and redirection logic to background.html:
<html><body> <script> chrome.webRequest.onBeforeRequest.addListener( function(details) { </script> </body></html>
source share