ID2 VS2010 settings are saved using the IDE, not with a project or solution. (Except, of course, for project settings / solutions, but I assume we are not talking about this)
After reading this msdn article, it seems like a common way to have different configuration sets is to use the import / export option with one xml file for each configuration set.
Maybe some addin could do the job, but at this time I don't know any features.
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