Which choice to choose depends on your situation, but I consider it this way:
If the process is completely background and not too critical, Lowest.
If the process should happen, but the time is not critical, below Normal.
If the process is just as important as everyone else, Normal.
I try not to use higher ones, my programs are not so important :)
As for the difference, it depends on the code run and what the OS decides to do with the priorities, it does not need to listen to the one you installed.
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